High throughput optimization procedure to characterize vitrification kinetics

Tracking chemical kinetics in high-throughput systems.

Combinatorial chemistry and high-throughput experimentation (HTE) have revolutionized the pharmaceutical industry-but can chemists truly repeat this success in the fields of catalysis and materials science? We propose to bridge the traditional "discovery" and "optimization" stages in HTE by enabling parallel kinetic analysis of an array of chemical reactions. We present here the theoretical bas...

End-to-End Optimization of High-Throughput DNA Sequencing

At the core of Illumina's high-throughput DNA sequencing platforms lies a biophysical surface process that results in a random geometry of clusters of homogeneous short DNA fragments typically hundreds of base pairs long-bridge amplification. The statistical properties of this random process and the lengths of the fragments are critical as they affect the information that can be subsequently ex...

High throughput pH optimization of protein crystallization.

Most high throughput structural proteomics centers use the sitting-drop method to obtain diffracting crystals for three-dimensional (3D) structure determination of biological macromolecules by x-ray crystallography. Although several robotic systems are available for dispensing the initial sitting-drop screening conditions, generally they are not used for optimization of crystallization conditio...

Transmission Optimization for High Throughput Satellite Systems

A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

Zebrafish have become an important alternative model for characterizing chemical bioactivity, partly due to the efficiency at which systematic, high-dimensional data can be generated. However, these new data present analytical challenges associated with scale and diversity. We developed a novel, robust statistical approach to characterize chemical-elicited effects in behavioral data from high-t...